Partial or complete lack of dihydropyrimidine dehydrogenase (DPD) enzyme functionality can increase the risk of severe drug toxicity during treatment with fluoropyrimidines (5-FU, capecitabine, tegafur). Understanding DPYD gene status and its impact on drug metabolism is a rapidly growing focus area in clinical research.
The VeriDose® DPYD Panel targets a set of 9 DPYD variants associated with an increased risk of severe toxicity, including the 5 variants recommended by the European Medical Agency and the 4 variants of primary relevance as noted by the Clinical Pharmacogenetics Implementation Consortium. The single well panel can be run either alone or side-by-side with other genotyping panels.