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HFE Genotyping Panel

CFTR PanelHFE Genotyping Panel

Comprehensive 6-variant hereditary hemochromatosis research panel for the MassARRAY® System

KEY ADVANTAGES:

  • Comprehensive 6-Variant Coverage: Most extensive HFE research panel available – includes recommended variants (C282Y, H63D, S65C) plus additional variants of interest for diverse population studies and academic research programs.
  • Streamlined Workflow: Single-well multiplexed assay eliminates multiple PCR reactions, reducing hands-on time and potential errors in research laboratory settings while maximizing efficiency.
  • Integrated Data Analysis: Built-in software analysis removes the need for extensive bioinformatics infrastructure, making advanced molecular research accessible to laboratories without specialized expertise.
  • Cost-Effective Solution: Optimized for laboratories running 100+ molecular tests monthly, offering superior cost-per-data point compared to traditional approaches with reduced reagent and labor costs.
Research Applications

The HFE Panel RUO supports diverse hereditary hemochromatosis research applications across multiple laboratory settings and research objectives.

Population genomics research represents a primary application for the HFE Genotyping Panel, enabling comprehensive variant analysis for studying hereditary hemochromatosis prevalence across diverse populations and geographic regions. Research laboratories conducting large-scale population studies benefit from the panel’s ability to capture genetic variants that may be more prevalent in specific ethnic groups or geographic populations, supporting epidemiological research and population health initiatives.

Academic medical centers and university research programs can utilize the HFE Genotyping Panel to support investigations into iron homeostasis, genetic epidemiology, and hereditary disorder research. The comprehensive variant coverage enables academic researchers to conduct thorough genetic studies, publish research findings, and contribute to the broader scientific understanding of hereditary hemochromatosis genetics across diverse patient populations.

Reference laboratories, both regional and national, can integrate the HFE Genotyping Panel to offer comprehensive HFE research testing services to their research collaborators and academic partners. The panel’s streamlined workflow and cost-effective design make it particularly suitable for reference laboratories that need to provide consistent, high-quality research data across multiple research projects and collaborations.

Why Comprehensive HFE Research Matters

As global populations become increasingly diverse and age demographics shift toward older populations, comprehensive HFE variant research becomes essential. Traditional 2-3 variant approaches may miss important genetic variants in diverse research populations. Our 6-variant research panel provides the most complete HFE genetic profile available for hereditary hemochromatosis research.

Learn more about HFE testing approaches and guidelines
Ordering Information
Product # of Samples Format Catalog #
HFE Genotyping Panel Set – CPM (2x96) 192 96 CPM 13391F
HFE Genotyping Panel Set – CPM (10x96) 960 96 CPM 13397F
HFE Genotyping Panel Set – CPM (2x384) 768 384 CPM 13396D
HFE Genotyping Panel Set – CPM (10x384) 3,840 384 CPM 13398D

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Brochure:

HFE Genotyping Panel Brochure

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White Paper:

The HFE Genotyping Panel is an RUO panel detecting six variants in the HFE gene

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Publication:

Contributions of HFE polymorphisms to brain and blood iron load, and their links to cognitive and motor function

View on Wiley.com

Most extensive HFE research panel available – includes recommended variants (C282Y, H63D, S65C) plus additional variants of interest for diverse population studies and academic research programs.

Frequently Asked Questions (FAQs)

What is HFE testing?

HFE gene research helps to identify variants associated with hereditary hemochromatosis (HH), an inherited condition that can lead to excess iron accumulation in the body. If undetected, iron overload may contribute to liver, heart, and endocrine dysfunction over time.

What are the key HFE testing guidelines and recommendations?

  • The American Association for the Study of Liver Diseases (AASLD) provides comprehensive guidelines for the diagnosis and management of HH focusing on identifying individuals at risk, confirming diagnoses, and guiding treatment to prevent complications. https://www.aasld.org/
  • The European Association for the Study of the Liver (EASL) provides comprehensive recommendations on the diagnosis and management of HH. https://easl.eu/
  • The Royal Australian College of General Practitioners (RACGP) guidelines, particularly within the “Genomics in General Practice” resource, offer evidence-based advice for general practitioners on the diagnosis and management of HH. https://www.racgp.org.au/

Which other panels does Agena Bioscience have?

Our pre-designed panels are available for on-demand ordering to get you up and running quickly. Each panel leverages our proven iPLEX® chemistry. Panels can be run simultaneously using the same workflow from beginning to end.

Other pre-designed panels include:

The VeriDose Core Panel v2.0 targets the most relevant variants in 16 key genes implicated in drug metabolism pathways. It provides genotype information for 85 Tier 1 and Tier 2 SNPs/INDELs recommended by leading societies for pharmacogenetics analysis.

The VeriDose CYP2D6 CNV Panel detects CNVs even in the presence of difficult to detect hybrid alleles. It interrogates 22 points in 7 regions of the CYP2D6 gene using a single well.

The VeriDose DPYD Plus Panel targets a set of 18 DPYD variants, including all AMP Tier 1 & Tier 2 recommended variants,to understand severe toxicity risk.

I need a custom solution, does Agena provide custom assay design services?

Agena Bioscience® provides two different options for users interested in creating custom genotyping, somatic mutation, or epigenetic assays. You can independently design and develop content using our online assay design software or partner with our scientists for assay development and verification services. Both options use the same chemistries, simple workflow, and application software for analysis. Our highly skilled scientists design and verify your research-use assays in the laboratory for superior performance. Learn more

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