Advance HFE gene research with speed,
accuracy and simplicity

Unlock confident HFE research with the industry’s most targeted, guideline-aligned genotyping solution.

Innovation in HFE research testing

People of European descentA targeted panel designed for cost-effective, high-confidence genetic research. Delivering coverage of the most relevant variants, rapid turnaround, and scalable throughput without the complexity of NGS.

Hereditary hemochromatosis (HHC) affects 1 in 200 people of Northern European descent, yet it remains under-tested in research. Many workflows focus only on the most common HFE variants, overlooking emerging targets important for diverse and aging populations.

In 2025, leading research guidance continues to recommend testing for C282Y, H63D, and S65C. Growing evidence also supports expanding coverage to include even more rare variants for more complete population studies.

The HFE Genotyping Panel from Agena Bioscience® delivers all guideline-recommended variants plus three emerging targets in a single-well workflow. It is designed for focused coverage, faster turnaround, and scalable efficiency while avoiding the complexities of NGS. The panel helps labs reduce reruns, avoid ambiguous calls, and enables them to process from as few as 1 to more than 1,000 samples per day with confidence.

Explore the HFE Panel

An HFE Genotyping Panel that detects all guideline-recommended variants

Built for HFE research, this panel delivers all guideline-recommended variants (C282Y, H63D, S65C) plus three additional emerging targets to address increasingly diverse and aging patient populations.

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SINGLE WELL

One-well assay with no need for complex bioinformatics.

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6 VARIANTS

Minimizes reruns and ambiguous calls seen with broad NGS panels.

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THROUGHPUT

Scalable throughput for any lab size — from 1 to 1,000+ samples/day.

One workflow, many applications

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Population & Epidemiology Studies

Assess variant prevalence across diverse ancestries.

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Family-Based & Clinical Research

Research inheritance patterns and support iron-overload studies.

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Biobank & Longitudinal Projects

Standardize high-throughput HFE genotyping across global sites.

Why targeted panels beat broad NGS

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  • FASTER TURNAROUND TIME (TAT)
  • GUIDELINE-ALIGNED VARIANTS
  • LOWER REAGENT WASTE
  • LOWER INTERPRETATIVE BURDEN

Proven lab impact

  • Reduced reagent waste & interpretive burden vs. broad NGS panels
  • Material costs are cut by 65% in customer implementations

Designed for global lab needs

  • Used in alpha sites in North and South America
  • UK/NL/DE: Guideline-aligned, cost-effective, high-volume fit
  • Australia/NZ: No bioinformatics workflow
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Need a refresher on the MassARRAY® System?

The HFE Genotyping Panel by Agena Bioscience® is built on the MassARRAY® System, designed under a robust quality system and optimized for high-efficiency research labs.
Learn More

“ When we switched from other testing platforms to the MassARRAY our cost of materials dropped by over 65% immediately. Implementing the MassARRAY technology in our laboratory, made it possible for us to cut the cost of running our tests...

– VP of Operations

Agena Bioscience Customer

Download the white paper

Stay ahead of what’s next in focused variant research

Download our pre-launch white paper and get early access to the performance white paper, which features real world data from beta testing sites.

  • View six key HFE variants, including top recommended and emerging targets for diverse populations.
  • Explore the workflow upfront: multiplex PCR and MassARRAY® with familiar iPLEX® chemistry.
  • Access trusted references: CDC-characterized DNA samples and commercial controls for evaluation.
Get the white paper now