Videos & Webinars

Webinar: A Pharmacogenetic (PGx) Blindspot: The Prevalence and Impact of CYP2D6 Hybrid Alleles

23 April 2020

Does your PGx detection method have blind spots? Sample mischaracterization can lead to inaccurate results. CYP2D6 is responsible for the metabolism and elimination of approximately 25% of clinically used medications. Depending on ethnicity, up to 37% of individuals possess a non-functional CYP2D6 hybrid allele. Common CYP2D6 genotyping and copy number detection methods cannot detect these alleles, resulting in pharmacogenetic profile mischaracterization. Dr. Houda Hachad will offer recommendations for overcoming this challenge to achieve a comprehensive CYP2D6 profile and more accurate PGx results.


  • What is a CYP2D6 hybrid allele?
  • How prevalent are CYP2D6 hybrid alleles across populations?
  • How does missing them affect PGx results?
  • What can be done to ensure accurate CYP2D6 characterization?

Presented By: Dr. Houda Hachad, Vice President of Clinical Operations, AccessDx

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